Transplant rejection diagnosis is difficult due to careful testing and patient examination. Although transplant rejection does not mean that you have lost your liver, it is very important to be diagnosed and treated quickly. The patient should continue normal life and not worrying about rejection. There is a cure for rejection in most cases, and this should not cause a disruption in your life. In many cases, liver biopsies are needed to accurately diagnose rejection. Don’t forget that the most important reason for liver rejection is having improper medication.

In mild to moderate cases of transplant rejection, the problem is usually resolved by increasing the dose of the medication. Methylprednisolone injections are used in severe cases or if increasing the drug dose does not respond well.

The drug is usually given on an outpatient basis and injected 500 to 1000 mg daily (one or two methylprednisolone ampoules) into the serum for up to three days, after which the tests are repeated. At the same time, the dose of Tacrolimus or other medications may be increased. Note that this drug will increase blood sugar, muscle weakness and bone pain. The patient will be more at risk for viral and fungal infections while taking this medicine. It is important to drink plenty of liquid during the day. Measure your blood sugar every six hours. Minimize salt intake to reduce swelling in your head, face, and limbs, as well as side effects. If you are not hospitalized, be sure to rest at home and avoid contacting with others and exposure to dust or people with respiratory illnesses or colds. If the liver rejection does not respond to this medication, you will need to have a supplementary test or, if you have had a previous biopsy, a new biopsy, in which case you will usually be hospitalized and the next line of medication will be used for you.

These include ATGs or monoclonal antibodies such as Campath or Simulect.