Liver transplant is not only a definitive way to cure advanced liver failure (cirrhosis), but it is also effective in treating some liver genetic disorders such as Crigler–Najjar syndrome. Nowadays, the number of known cirrhosis patients is increasing and thanks to the scientific advances, the diagnosis of this disease has become easier

Lack of organ for transplantation is one of the major problems of transplant centers all around the world, therefore, a significant number of patients due to liver deficiency and delay in performing transplant surgery, get serious problems and they might even face death. Although in recent years, a collaboration of self-sacrificing people and organ donation from brain dead patients has increased, there are still many patients who look forward to organ donation. Statistical data shows that, in adults, one out of two people has a chance of having liver transplantation from a brain death but it is much lower in children.
Since 1989 that the first partial related transplantation was done, a piece of liver of a 29-year-old mother was donated to her son. The success of this transplantation and the possibility of donating part of a liver by first-degree relatives has made a tremendous evolution in saving advanced cases of liver patients. In Shiraz, more than 500 related transplants have been done so far, meanwhile, the first partial transplant in this center was done in 1997.